Biological Effects of Alcohol by Henri Begleiter (eds.)

By Henri Begleiter (eds.)

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L. HOFFMAN AND B. I It: ~ 30- Z 20 .... I 0- tJ I'a1 0 Eo< < ~ z !... i I ~ ~ • ,.!. ( ~ ~ '" FIGURE 1. ~·1easures of dopaminergic receptor function in C57Bl/6 mice treated chronically with ethanol (9) and \'1ithdrawn for 24 hrs. p. injection of 40 mg/kg piribedil (13). p. injection of 4 mg/kg apomorphine (14). p. injection of saline of 1 mg/kg pimozide, respectively (78). Data is presented as percent decrease in each response in the ethanol-withdrawn animals as compared with controls. Varying numbers o"f animals were used in each test system; see appropriate references.

24: 744-747, 1972. 76. , Kehr, W. and Lindqvist, M. Agonist-antagonist interactionon dopamine receptors in brain, as reflected in the rates of tyrosine and tryptophan hydroxylation. J. Neural. Trans. 40: 99-113, 1977. 77. , Guidotti, A. and Costa, E. The regulation of the kinetic peak of strial tyrosine hydroxylase and the role of post-synaptic dopamine receptors. Brain Res. 92: 516-521,1975. 78. Tabakoff, B. L. Alterations in receptors controll ing dopamine synthesis after chronic ethanol ingestion.

Effects of acute and chronic ethanol administration and withdrawal on adenosine 3' ,5'-r~nophosphate and guanosine 3',5'-monophosphate levels in the rat brain. J. Pharm. Exptl. Ther. 200: 298-305, 1977. 38. W. Biochemical regulation and physiological significance of cycl ic nucleotides in the central nervous system in Greengard, P. A. ) Adv. Cycl ic Nucl. , Vol. 8. Raven Press, New York:-i977, pp. 421-508. , Bennett, V. and Jacobs, S. Irreversible stimulation of adenylate cyclase activity of fat cell membranes by phosphoramidate and phosphorate analogs of GTP.

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