Biomimetic Materials And Design: Biointerfacial Strategies, by Angela Dillow, Anthony Lowman

By Angela Dillow, Anthony Lowman

Offers tips on how to strengthen man made and organic fabrics with greater in vivo houses. Considers the impact of topographical positive aspects on phone behaviors reminiscent of orientation, adhesion, migration, proliferation, and differentiation.

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Extra info for Biomimetic Materials And Design: Biointerfacial Strategies, Tissue Engineering And Targeted Drug Delivery

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Principle A common biomolecular strategy in the engineering of adhesive surfaces is to present small peptides encoding the recognition sequences, such as RGD and YIGSR, of several extracellular ligands. While this strategy supports integrin-mediated cell adhesion, several integrins, including a5 b1 and aIIb b3 , require additional binding domains in FN. Targeting of specific integrins is critical to control of cell function since different integrins trigger diverse signaling cascades (51). Therefore, biomolecular approaches to develop bioadhesive surfaces should not be limited to the RGD site but should extend to additional domains of FN required for full activity, such as the PHSRN synergy site.

Surfaces modified with covalently-immobilized adhesive peptides affect fibroblast population motility. Biomaterials 17(8):759–764, 1996. 10. A Renzania, CH Thomas, AB Branger, CM Waters, KE Healy. The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein. J Biomed Mater Res 37(1):9–19, 1997. 11. YW Tong, MS Shoichet. Peptide surface modification of poly(tetrafluoroethylene-co-hexafluoropropylene) enhances its interaction with central nervous system neurons.

In the modified JKR apparatus, two opposing surfaces are brought into contact in an aqueous environment under an applied load. The contact area formed between the two surfaces is measured as a function of the normal load, as shown in Fig. 11a. An energy balance is used to calculate the adhesion energy (G) as a function of the normal load, contact area, radius of curvature, and elastic moduli of the surfaces. Differences in the measured adhesion as the surfaces are brought together (advancing) and then pulled apart (receding) provide information about adhesion resulting from the interaction between the integrin and ligand(s) surfaces.

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